Brevity of the Inductive Phase in the Immune Response of Mice to Capsular Polysaccharide Antigens

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Abstract
Summary: The antigen-bentonite adherence technique, used in conjunction with capsular polysaccharide antigens, has revealed features of the cytokinetics of the immune response not demonstrable with other categories of antigens and other methods. In particular, the immune response of mice to type I pneumococcal polysaccharide and the Vi galactoseaminuronic polymer showed an exceedingly brief latent period after which antigenreactive cells (ARC) appeared within a few hours following immunization. Thereafter, ARC doubled at a rate too rapid to be accounted for by cell division alone. The brevity of the inductive phase, the rate at which ARC increased and the maximum numbers of ARC attained depended on the dose of antigen.

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