The activity of nitro-compounds against Bacteroides fragilis is related to their electron affinity
- 1 August 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Antimicrobial Chemotherapy
- Vol. 8 (2) , 91-99
- https://doi.org/10.1093/jac/8.2.91
Abstract
The in-vitro activity of 30 nitro-compounds was tested against Bacteroides fragilis NCTC 9343. The results using 24 drugs correlated with their electron affinities (r = 0·8086) and fitted the equation: —Log10C=0·190−(6·35 ± 0·99)E where C is the MIC in mmol/I, and Ē is the one-electron reduction potential in volts. It was found that when partition coefficient terms were included, the correlation was not improved. Possible explanations for the results with six compounds that did not fit this relationship are also discussed.Keywords
This publication has 1 reference indexed in Scilit:
- Structure-activity Relationships in the Development of Hypoxic Cell RadiosensitizersInternational Journal of Radiation Biology, 1979