Improved Syntheses of Chlorodeoxynucleosides
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 6 (8) , 563-573
- https://doi.org/10.1080/00397917608063550
Abstract
Halodeoxynucleosides are very useful intermediates in the synthesis of nucleoside and nucleotide derivatives. Because the iodides are more reactive,1 the corresponding chlorides have received relatively little attention although 5′-chloro-5′-deoxyadenosine (1) is effective in controlling blood pressure,2 and has been employed in a novel approach to the synthesis of polynucleotides.3 Other halonucleosides have been cited as potentially important antibiotics.1Keywords
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