Analysis of Protein Conformation and Dynamics by Hydrogen/Deuterium Exchange MS
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- 7 August 2009
- journal article
- other
- Published by American Chemical Society (ACS) in Analytical Chemistry
- Vol. 81 (19) , 7870-7875
- https://doi.org/10.1021/ac901154s
Abstract
Understanding as much as possible about proteins in the shortest amount of time has long been a goal of hydrogen exchange (HX) MS. Recent technological advances have led to improvements in the technique, but has this goal yet been achieved? (To listen to a podcast about this Feature, please go to the Analytical Chemistry Web site at pubs.acs.org/journal/ancham.).Keywords
This publication has 43 references indexed in Scilit:
- Characterization of IgG1 Conformation and Conformational Dynamics by Hydrogen/Deuterium Exchange Mass SpectrometryAnalytical Chemistry, 2009
- Emerging trends in plasma‐free manufacturing of recombinant protein therapeutics expressed in mammalian cellsBiotechnology Journal, 2009
- KIT kinase mutants show unique mechanisms of drug resistance to imatinib and sunitinib in gastrointestinal stromal tumor patientsProceedings of the National Academy of Sciences, 2009
- Construct optimization for protein NMR structure analysis using amide hydrogen/deuterium exchange mass spectrometryProteins-Structure Function and Bioinformatics, 2009
- HD desktop: An integrated platform for the analysis and visualization of H/D exchange dataJournal of the American Society for Mass Spectrometry, 2008
- Detection and Characterization of Altered Conformations of Protein Pharmaceuticals Using Complementary Mass Spectrometry-Based ApproachesAnalytical Chemistry, 2008
- High-Speed and High-Resolution UPLC Separation at Zero Degrees CelsiusAnalytical Chemistry, 2008
- Intrinsically unstructured proteins and their functionsNature Reviews Molecular Cell Biology, 2005
- Production of recombinant protein therapeutics in cultivated mammalian cellsNature Biotechnology, 2004
- Hydrogen-deuterium exchange as a probe of folding and assembly in viral capsids11Edited by C. R. MatthewsJournal of Molecular Biology, 2001