MIC and fungicidal activity of terbinafine against clinical isolates of Aspergillus spp
- 1 May 1988
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 32 (5) , 780-781
- https://doi.org/10.1128/aac.32.5.780
Abstract
Terbinafine and amphotericin B MICs for 90% of strains tested were 1.6 and 0.4 micrograms/ml against Aspergillus fumigatus (16 strains), 0.8 and 3.2 micrograms/ml against Aspergillus flavus (10 strains), and 0.4 and 1.6 micrograms/ml against Aspergillus niger (10 strains), respectively. For all species tested, the minimal inhibitory and fungicidal concentrations for 90% of strains of both drugs were identical and the inoculum size did not have a major effect on the results.This publication has 6 references indexed in Scilit:
- Antifungal activity of the allylamine derivative terbinafine in vitroAntimicrobial Agents and Chemotherapy, 1987
- Inhibition of squalene epoxidase by allylamine antimycotic compounds. A comparative study of the fungal and mammalian enzymesBiochemical Journal, 1985
- Specific inhibition of fungal sterol biosynthesis by SF 86-327, a new allylamine antimycotic agentAntimicrobial Agents and Chemotherapy, 1985
- In-vitro studies with SF 86–327, a new orally active allylamine derivativeMedical Mycology, 1985
- Synthesis and antifungal activity of (E)-N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine (SF 86-327) and related allylamine derivatives with enhanced oral activityJournal of Medicinal Chemistry, 1984
- Effect of the antimycotic drug naftifine on growth of and sterol biosynthesis in Candida albicansAntimicrobial Agents and Chemotherapy, 1984