Assignment of a Locus for Familial Melanoma, MLM, to Chromosome 9p13-p22
- 13 November 1992
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 258 (5085) , 1148-1152
- https://doi.org/10.1126/science.1439824
Abstract
Linkage analysis of ten Utah kindreds and one Texas kindred with multiple cases of cutaneous malignant melanoma (CMM) provided evidence that a locus for familial melanoma susceptibility is in the chromosomal region 9p13-p22. The genetic markers analyzed reside in a candidate region on chromosome 9p21, previously implicated by the presence of homozygous deletions in melanoma tumors and by the presence of a germline deletion in an individual with eight independent melanomas. Multipoint linkage analysis was performed between the familial melanoma susceptibility locus (MLM) and two short tandem repeat markers, D9S126 and the interferon-alpha (IFNA) gene, which reside in the region of somatic loss in melanoma tumors. An analysis incorporating a partially penetrant dominant melanoma susceptibility locus places MLM near IFNA and D9S126 with a maximum location score of 12.71. Therefore, the region frequently deleted in melanoma tumors on 9p21 presumably contains a locus that plays a critical role in predisposition to familial melanoma.Keywords
This publication has 27 references indexed in Scilit:
- Cutaneous malignant melanoma and atypical moles associated with a constitutional rearrangement of chromosomes 5 and 9American Journal of Medical Genetics, 1993
- Mapping of the shortest region of overlap of deletions of the short arm of chromosome 9 associated with human neoplasiaGenomics, 1992
- Genetic and physical map of the interferon region on chromosome 9pGenomics, 1992
- Genetic Analysis Workshop 7: Summary of the melanoma workshopCytogenetic and Genome Research, 1992
- Exclusion of the familial melanoma locus (MLM) from the
PND D1S47 Genomics, 1992 - Stress Response Protein (srp-27) Determination in Primary Human Breast Carcinomas: Clinical, Histologic, and Prognostic CorrelationsJNCI Journal of the National Cancer Institute, 1991
- Cytogenetics of non‐small cell lung cancer: Analysis of consistent non‐random abnormalitiesGenes, Chromosomes and Cancer, 1990
- Mapping the Gene for Hereditary Cutaneous Malignant Melanoma–Dysplastic Nevus to Chromosome LpNew England Journal of Medicine, 1989
- Other Possible Mechanisms of AIDS Retrovirus PathenogenicityJNCI Journal of the National Cancer Institute, 1989
- Arguments in favor of a polygenic inheritance of precursor neviJournal of the American Academy of Dermatology, 1982