Cerebrodiene: a brain lipid isolated from sleep-deprived cats.
- 27 September 1994
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 91 (20) , 9505-9508
- https://doi.org/10.1073/pnas.91.20.9505
Abstract
We report the isolation of a heretofore unrecognized brain lipid that is present in cerebrospinal fluid of sleep-deprived cats. The molecule appears to be a long-chain base structurally related to sphingosine and sphinganine in which a second unsaturated bond has been introduced. An increase in the degree of unsaturation of a key membrane component is expected to have important physiological consequences.Keywords
This publication has 7 references indexed in Scilit:
- The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signalingPublished by Elsevier ,1994
- Lipid second messengersCell, 1994
- The sphingomyelin cycle and the second messenger function of ceramide.Journal of Biological Chemistry, 1994
- Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide.Journal of Biological Chemistry, 1993
- Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular RegulationScience, 1989
- Acetonitrile-hydrochloric acid hydrolysis of gangliosides for high performance liquid chromatographic analysis of their long chain bases.Journal of Lipid Research, 1983
- CONTROL OF FATTY ACID COMPOSITION IN PHOSPHOLIPIDS OF Escherichia coli : RESPONSE TO FATTY ACID SUPPLEMENTS IN A FATTY ACID AUXOTROPHProceedings of the National Academy of Sciences, 1969