RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
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- 17 July 2009
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 325 (5938) , 332-336
- https://doi.org/10.1126/science.1172308
Abstract
The Grim RIPper: Cells can undergo regulated cell death through distinct processes known as apoptosis and necrosis. Regulation of apoptosis is better understood than that of necrosis. In a screen for gene products that participate in control of necrosis in cells treated with TNF (tumor necrosis factor), D.-W. Zhang et al. (p. 332 ; published online 4 June) identified a protein kinase, RIP3. In cells treated with TNF and a caspase inhibitor that inhibits apoptosis, seven metabolic enzymes interacted with RIP3, some of which are associated with mitochondria. Generation of reactive oxygen species was necessary for TNF-induced necrosis, and depletion of RIP3 reduced the generation of reactive oxygen species. Thus, RIP3 may participate in the mechanisms that link energy metabolism with mechanisms of cell death.Keywords
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