Genetic analysis of transmission ratio distortion byt-haplotypes in the mouse

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Abstract
SUMMARY: Lethal and semilethalt-haplotypes in the mouse are polymorphic in wild populations, where they are presumably maintained by transmission distortion from males, which transmit the aberrant chromosome to over 95% of progeny. We report here measurements of transmission ratio that show an unexpectedly strong effect of background genotype, specifically genes on the homologous chromosome, on the degree of transmission distortion oft-haplotypes. We also provide additional evidence that withint-haplotypes two separable elements co-operate to control transmission distortion, and that the system is thus closely analogous to segregation distortion in Drosophila, as has been previously proposed by Gluecksohn-Waelsch & Erickson (1970), Demin, Safronova & Lapkina (1978), and Styrna & Klein (1982).