Insulin-Like Growth Factor Gene Expression during Rat Embryonic Development*
- 1 December 1987
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 121 (6) , 2141-2144
- https://doi.org/10.1210/endo-121-6-2141
Abstract
The function of insulin-like growth factors I and II (IGF-I and IGF-II) in embryogenesis is unknown. To investigate the ontogeny of IGF gene expression during mammalian development we used a highly sensitive and specific solutionhybridization assay to determine the steady state levels of IGF mRNAs during midgestation in the rat. IGF-I mRNA can be detected as early as day 11 of embryonic development and rises 8.6-fold over the ensuing 48 h. By contrast IGF-II mRNA is relatively constant over days 11-14 of gestation. These observations suggest that both IGFs may play important roles in early fetal development. (Endocrinology121: 2141–2144, 1987)Keywords
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