Initial bolus of conventional versus high‐dose dexamethasone in metastatic spinal cord compression
- 1 September 1989
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 39 (9) , 1255
- https://doi.org/10.1212/wnl.39.9.1255
Abstract
We randomly assigned dexamethasone in an initial bolus of 10 mg IV or 100 IV followed by 16 mg daily orally to 37 patients with metastatic spinal cord compression. The average pain score before the start of treatment was 5.2 (SD = 2.8) and decreased significantly (p < 0.001) to 3.8 at 3 hrs, 2.8 at 24 hrs, and 1.4 after 1 week. There were no differences between the conventional and high-dose group of pain, ambulation, or bladder function.This publication has 6 references indexed in Scilit:
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- Treatment outcome and complications in patients treated for malignant epidural spinal cord compression (SCC)Journal of Neuro-Oncology, 1985
- Treatment of experimental spinal cord compression caused by extradural neoplasmsJournal of Neurosurgery, 1977