Relationship Between Serum Amino Acid Concentration and Fluctuations in Appetite

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Abstract
In normal volunteers and patients without diseases known to affect protein or carbohydrate metabolism crude estimations of appetite were correlated with the serum amino acid and blood sugar concentrations in 4 circumstances: (a) after a 20-g protein breakfast, (b) after infusions of hydrolyzed casein and glucose, (c) after infusions of hydrolyzed casein alone and (d) after the ingestion of hydrolyzed casein. In all 4 experiments there was a reciprocal relationship between the serum amino acid concentration and appetite. A similar relationship between the blood sugar concentration and appetite was found after infusions of glucose and hydrolyzed casein, but the administration of hydrolyzed casein alone caused the blood sugar concentration and the appetite to diminish simultaneously.

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