Failure of somatostatin to influence experimental tumor cell growth in vivo and in vitro
- 1 September 1981
- journal article
- research article
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 37 (9) , 1015-1017
- https://doi.org/10.1007/bf01971812
Abstract
The influence of somatostatin on tumor cell growth was studied in vivo in mice (sarcoma 180 ascites tumor and Lewis lung tumor) and in vitro on nontransformed and polyoma-transformed cell lines. 4 or 20 μg/100 g of cyclic somatostatin and 4 μg/100 g of linear protamin Zn-bound somatostatin were injected s.c. twice daily in the in vivo study. Cyclic somatostatin (1, 4 or 10 μg/ml) was added twice daily to the cell cultures. Somatostatin administration influenced neither the survival of animals nor the growth rate of cultured cell lines. *** DIRECT SUPPORT *** A2025117 00011This publication has 9 references indexed in Scilit:
- Effect of Somatostatin on Normal and Gastric-Stimulated Cell Proliferation in the Gastric and Intestinal Mucosae of the RatDigestion, 1979
- Effect of in vivo administration of somatostatin on cell-free protein synthesis of pituitary and of adrenal ribosomesMetabolism, 1978
- Investigations of the antiproliferative effect of somatostatin in man and ratsMetabolism, 1978
- Somatostatin reduces the release of colony-stimulating activity (CSA) from PHA-activated mouse spleen lymphocytesCellular and Molecular Life Sciences, 1978
- Temperature-sensitive growth regulation in one type of transformed rat cells induced by the tsa mutant of polyoma virusJournal of Virology, 1977
- Inhibition by somatostatin of adenosine-3?,5?-monophosphate stimulated hepatic ribosomal protein synthesisJournal of Molecular Medicine, 1977
- Trophic effects of gastrointestinal hormones: physiological implications.1977