P‐31 Magnetic Resonance Spectroscopy in Polymyositis and Dermatomyositis

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Abstract
Objective. To explore alterations in energy utilization as a potential etiology for weakness in polymyositis and dermatomyositis (PM/DM). Methods. P‐31 magnetic resonance spectroscopy studies were performed in patients with acute and treated PM/DM and in normal controls, at rest and with exercise. Results. Patients with acute and treated PM/DM showed increased ratios of inorganic phosphate to phosphocreatine (PCr) during exercise, with loss of ATP disproportional to loss of PCr. Conclusion. This study demonstrates changes in energy utilization in PM/DM, thus supporting the notion of a metabolic etiology for the weakness associated with these diseases.