Antitumor Effect of Recombinant Murine Interferon-β against Mouse Malignant Glioma

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Abstract
A study was made on the antitumor effect of recombinant murine interferon-β (rMuIFN-β) against virus-induced mouse malignant glioma. In in vitro experiments, a dose-dependent and a time-dependent manner were observed for 24 h in the antiproliferative activity of rMuIFN-β. In in vivo experiments, the growth of subcutaneously transplanted gliomas in mice treated with intraperitoneal administration of rMuIFN-β was inhibited slightly, whereas, with intratumoral administration, it was inhibited more effectively. In immunological studies, natural killer (NK) cell and cytotoxic T-lymphocyte activities of spleen cells were enhanced with intraperitoneal administration of rMuIFN-β. The analysis of IFN-induced change in a subpopulation of peripheral blood lymphocytes revealed a decrease of Thy. 1,2-positive cells and an increase in the ratio of Lyt.l/Lyt.2-positive cells. But these immunological effects of rMuIFN-β declined on the 7th day with daily administration. Such hyporeactivity may be noteworthy for the clinical application of IFN.

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