Regulation of86Rb outflow from pancreatic islets

1 July 1980

journal article
research article
Published by Springer Nature in Acta Diabetologica

Vol. 17 (3-4) , 199-205
https://doi.org/10.1007/bf02581319

Abstract

Theophylline (1.4 mM), cyclic AMP (1.0 mM) and dibutyryl-cyclic AMP (0.5 mM) decreased⁸⁶Rb fractional outflow rate from pancreatic islets perifused in the absence of glucose. In the presence of glucose (16.7 mM), however, the same drugs provoked a modest increase in⁸⁶Rb fractional outflow rate. The increase in⁸⁶Rb outflow evoked by theophylline in the presence of glucose was suppressed by quinine, suggesting that it may result from an increase in cytosolic Ca²⁺ concentration. It is proposed that changes in the cyclic AMP content of islet cells may participate in the regulation of K⁺ conductance by insulin secretagogues.

Keywords

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