Effect of a lignan (HPMF) on RNA synthesis in the rat uterus

Abstract
HPMF [trans(.+-.)-3,4-bis[(3-hydroxyphenyl)methyl] dehydro-3-furanone], at doses of 0.01-1 mg/kg, had no effect on uterine RNA synthesis over a period of 24 h. It significantly depressed estrogen-stimulated RNA synthesis if administered 22 h before estradiol but not if given 10 h before or together with the hormone.