Tendon Xanthomas in Familial Hypercholesterolemia Are Associated With Cardiovascular Risk Independently of the Low-Density Lipoprotein Receptor Gene Mutation
- 1 September 2005
- journal article
- research article
- Published by Wolters Kluwer Health in Arteriosclerosis, Thrombosis, and Vascular Biology
- Vol. 25 (9) , 1960-1965
- https://doi.org/10.1161/01.atv.0000177811.14176.2b
Abstract
Objective— To investigate the significance of tendon xanthomas (TX) in heterozygous subjects with familial hypercholesterolemia (hFH). Methods and Results— 951 men and women with genetic diagnosis ... In 951 subjects with hFH, significance of TX was studied. 278 (29.2%) presented TX (TX+) and 102 TX+ reported premature CVD (36.7%) versus 93 TX− (13.8%) (P=0.001). Age, male sex, LDL cholesterol, ...Keywords
This publication has 20 references indexed in Scilit:
- Reliable Low-Density DNA Array Based on Allele-Specific Probes for Detection of 118 Mutations Causing Familial HypercholesterolemiaClinical Chemistry, 2005
- Genetic polymorphisms affecting the phenotypic expression of familial hypercholesterolemiaAtherosclerosis, 2004
- Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemiaAtherosclerosis, 2004
- Familial Hypercholesterolemia in Spain: Case-Finding Program, Clinical and Genetic AspectsSeminars in Vascular Medicine, 2004
- Apolipoprotein E genotype is not associated with cardiovascular disease in heterozygous subjects with familial hypercholesterolemiaAmerican Heart Journal, 2003
- A review on the diagnosis, natural history, and treatment of familial hypercholesterolaemiaAtherosclerosis, 2003
- Hipercolesterolemia familiar heterocigota en España. Estudio descriptivo de 819 casos no relacionadosMedicina Clinica, 2002
- Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136 → Ser) variant in multigenerational pedigree studiesAtherosclerosis, 1996
- Risk of fatal coronary heart disease in familial hypercholesterolaemia. Scientific Steering Committee on behalf of the Simon Broome Register Group.BMJ, 1991
- Hyperlipidemia in Coronary Heart Disease II. GENETIC ANALYSIS OF LIPID LEVELS IN 176 FAMILIES AND DELINEATION OF A NEW INHERITED DISORDER, COMBINED HYPERLIPIDEMIAJournal of Clinical Investigation, 1973