Hepatic Veno-Occlusive Disease Caused by 6-Thioguanine

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Abstract
Clinically reversible veno-occlusive disease of the liver developed in a 23-yr-old man with acute lymphocytic leukemia after 10 mo. of maintenance therapy with 6-thioguanine. Serial liver biopsies showed the development and resolution of intense sinusoidal engorgement. Although this disease was clinically reversible, some subintimal fibrosis about the terminal hepatic veins persisted. This case presented a unique opportunity to observe the histologic features of clinically reversible hepatic veno-occlusive disease over time, and may be the 1st case of veno-occlusive disease related solely to 6-thioguanine.