THIP: A single-blind controlled trial in patients with epilepsy
- 1 February 1983
- journal article
- research article
- Published by Hindawi Limited in Acta Neurologica Scandinavica
- Vol. 67 (2) , 114-117
- https://doi.org/10.1111/j.1600-0404.1983.tb04552.x
Abstract
In an early phase-2 study, THIP (4,5,6,7-tetrahydroisoxazolo(5,4-c) pyridin-3-ol) was investigated in a single-blind controlled trial comprising 9 outpatients suffering from epilepsy. THIP was added to the concomitant antiepileptic treatment with increasing doses (15 to 120 mg/day) based on therapeutic effect or side-effects. The blood levels of concomitant therapy were kept constant. No significant difference was established between the number of seizures during treatment with maximal doses of THIP and placebo. A trend was observed for lower seizure frequency during a period on submaximal dose of THIP.Keywords
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