THE RELIEF OF TIC DOULOUREUX WITH STILBAMIDINE
- 1 February 1953
- journal article
- research article
- Published by American College of Physicians in Annals of Internal Medicine
- Vol. 38 (2) , 335-338
- https://doi.org/10.7326/0003-4819-38-2-335
Abstract
A review of the properties of stilbamidine (4:4′ stilbenedicarboxamidine) and observation of patients treated for various diseases with the drug revealed that its late chronic toxicity was confined to an unusual neuropathy. The progressive sensory changes of paresthesia, hypalgesia and anesthesia, usually confined to the face, were noted two to five months after a course of stilbamidine.1, 4, 5, 12, 13, 15, 16 Napier and Sen Gupta13 found a subjective disturbance of sensation over various distributions of the fifth cranial nerves. They suggested that the lesion was in the sensory nucleus of the trigeminal nerve in the pons. Collard andKeywords
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