Platelet activating factor as a proinflammatory mediator in acetic-induced colitis in the rat

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Abstract
Platelet activating factor (PAF) induces neutrophilia and produces a variety of gastrointestinal lesions. The role of PAF as a proinflammatory mediator was examined by measuring the production of PAF and the efficacy of the PAF antogonists WEB 2086 and Ro 24-0238 in acetic acid (HOAc)-induced colitis. PAF levels within the colonic mucosa, as measured by radioimmunoassay, increased from 259±119 ng/mg in control tissue, to 616±266 ng/mg in HOAc inflamed tissue. The accumulation of neutrophils within the mucosa was decreased by 53±10% by pretreatment with 3 mg/kg WEB 2086, and by 43±11% by 3 mg/kg Ro 24-0238. PAF-induced neutrophilia had no effect on the severity of HOAc-induced colitis, therefore, PAF my be involved in sustaining the chronic inflammation of colitis.