Competence Modulation by the NADH Oxidase of Streptococcus pneumoniae Involves Signal Transduction

Open Access
Publisher Website
Google Scholar
Abstract
Oxygen controls competence development in Streptococcus pneumoniae . Oxygen signaling involves the two-component signal transduction systems CiaRH and ComDE and the competence-stimulating peptide encoded by comC and processed by ComAB. We found that NADH oxidase (Nox) was required for optimal competence. Transcriptional analysis and genetic dissection showed that Nox was involved in post-transcriptional activation of the response regulator ComE and in the transcriptional control of ciaRH and comCDE . Thus, in S. pneumoniae, Nox, with O 2 as its secondary substrate, is part of the O 2 -signaling pathway.