HCS-HCG REGULATION IN CULTURED PLACENTA

Publisher Website
Google Scholar
Abstract
Tissue culture was used to study the action of different substrates on the secretion of HCG [human chorionic gonadotropin] and HCS [human chorionic somatomammotropin] in human placental explants. The following compounds were studied: prostaglandins [PG] E2 and F2.alpha., adrenaline [epinephrine] and noradrenaline [norepinephrine] estriol and progesterone, glucose concentration. The investigators 1st measured the normal secretion of 3 term placentas and 2 mo. placentas. The activity of the compounds tested is expressed in per cent of the normal values. The investigators checked that the cultivated cells were always viable by measuring the O2 consumption. PG E2 and F2.alpha. are without action on term placentas. Adrenaline and noradrenaline reduce significantly the secretion of HCS by full term placentas and have no action of HCG secretion. Estriol always stimulates HCS secretion by full term placentas and 2 mo. old placentas, whereas progesterone stimulates young placentas and inhibits full term placentas. Both steroids have no action on HCG secretion. Glucose is essential for HCS secretion by placentas by high values of glucose in the medium significantly reduce to HCS secretion by full term placentas.

This publication has 1 reference indexed in Scilit: