PITUITARY ADENOMAS THAT CAUSED CUSHINC'S DISEASE OR NELSON'S SYNDROME ARE NOT RESPONSIVE TO OVINE CORTICOTROPIN-RELEASING FACTOR IN VITRO
- 1 February 1983
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 56 (2) , 414-416
- https://doi.org/10.1210/jcem-56-2-414
Abstract
The response of pituitary adenomas obtained surgically from patients with Cushing's disease or Nelson's syndrome to synthetic ovine corticotropin-releasing factor (CRF), vasopressins, somatostatin-28, dexamethasone, 3-isobutylmethylxanthine or high [K+] was examined in vitro by measuring the amount of pro-opiomelanocortin (POMC)-derived peptides secreted into the culture medium. CRF did not stimulate the secretion of adrenocorticotropin-, β-endorphin-, or ϒmelanotropin-like peptides from the pituitary adenomas at concentrations ranging from 1⊠10-13 M to 1x10-7 M whereas vasopressins, 3-isobutyl-methylxanthine and high [K+] increased, while somatostatin-28 and dexamethasone suppressed, the secretion of these POMC-derived peptides. These findings suggest that either the pituitary ACTH-producing tumors have lost their receptors to CRF or their post-receptor mechanism to CRF is not functional.Keywords
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