Captopril bei essentieller Hypertonie

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Abstract
The antihypertensive effect of captopril was tested on 19 patients with essential hypertension, WHO grade I or II. In 11 patients blood pressure levels returned to normal over 12 wk at a dose of 3 .times. 50-150 mg daily (group A). In 8 patients with grade II hypertension the absolute blood-pressure reduction was the same, but did not reach normal levels (group B). Although additional intake of propranolol, at a dose of 3 .times. 40 mg daily, achieved futher reduction, normal pressures were still not attained. Initial blood pressure levels were higher and plasma renin activity (PRA) lower in patients of group B than of group A. There was a definite rise in PRA with captopril, but corresponding to the suppression of plasma renin in severe hypertension it was less. There was a fall in plasma aldosterone levels, corresponding to a reduced angiotension II level due to inhibition of the converting enzyme. The fall in plasma aldosterone activity was less in severe hypertension, but there was the same inhibition of converting enzyme activity in both groups. Normochromic anemia was noted in 3 patients, requiring further observation and explanation. No patient developed orthostatic hypotension or reflex tachycardia.