The inactive to active renin ratio in the kidneys and the plasma in diabetic nephropathy.
- 1 January 1983
- journal article
- research article
- Published by Japanese Circulation Society in Japanese Circulation Journal
- Vol. 47 (1) , 49-53
- https://doi.org/10.1253/jcj.47.49
Abstract
The inactive to active renin ratio in the renin granules of cadaver kidneys and plasma in patients with diabetic nephropathy was examined. The inactive renin in the break-through fraction when the plasma or the renin from the renin granules was put into a pepstatin column was determined. The inactive renin in this fraction was activated by trypsin. Concerning plasma, the inactive to active renin ratio was 90 in the patients and 9 in the normal subjects. This ratio was 0.29 in the patients'' kidneys and 0.28 in the control kidneys. Apparently, the increase of the inactive to active renin ratio in plasma of diabetic nephropathy does not result from the change of the renin storage in the kidneys.This publication has 8 references indexed in Scilit:
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