DOSE REQUIREMENTS OF PROPOFOL BY INFUSION DURING NITROUS OXIDE ANAESTHESIA IN MAN

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Abstract
The study was performed to determine the ED50 and ED95 of a continuous infusion of the emulsion formulation of propofol during 67% nitrous oxide anaestheisa in 57 patients premed-icated with morphine sulphate 0.15 mg kg−1. Anaesthesia was induced with propofol 2 mg kg−1, and maintained before incision with a fixed-rate infusion of propofol to supplement nitrous oxide. The response to the first surgical incision, made at least 30 min after induction of anaesthesia, was observed. The ED50; was 53.5 μg kg−1 min−1 and the ED95 was 112.2 μg kg−1 min−1. At the time of the first surgical incision, the venous whole blood concentrations of propofol at the ED50 and ED95 infusion rates (EC50and EC95 were 1.66 μg ml−1 and 3.39 fig ml−1 respectively. The satisfactory maintenance of anaesthesia provided by nitrous oxide supplemented with propofol was associated with stability and rapid, uncomplicated recovery.