RESEARCH ON ANTIBACTERIAL AND ANTIFUNGAL COMPOUNDS .8. SYNTHESIS AND ANTIFUNGAL ACTIVITY OF PYRROLE DERIVATIVES SIMILAR TO TRICOSTATIN-A
- 1 December 1987
- journal article
- research article
- Vol. 42 (12) , 893-903
Abstract
Some p-methylbenzoylpyrrole acrylic acids and related compounds were synthesized. The new pyrrole derivatives have structural features in common with trichostatin A, an antifungal antibiotic. The above acids and derivatives were tested against Candida albicans and Candida sp in comparison with micronazole, pyrrolnitrin and amphotericin B and showed very weak antifungal activities. Occasionally some activity was found against a few strains of Candida albicans and against Candida pseudotropicalis.This publication has 2 references indexed in Scilit:
- The total synthesis of (± )-trichostatin ATetrahedron, 1983
- Non‐Steroidal antiinflammatory agents. 1. A novel synthesis of 1‐methyl‐5‐p‐tolylpyrrole‐2‐acetic acid (tolmetin)Journal of Heterocyclic Chemistry, 1982