Potentiation and Its Mechanism of Cochlear Damage Resulting from Furosemide and Aminoglycoside Antibiotics

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Abstract
The severe ototoxic interaction of the combined administration of furosemide and aminoglycoside antibiotics (kanamycin, streptomycin and gentamicin) was studied in rabbits, and its mechanism clarified. Severe damage occurred in the inner ear and kidney when both furosemide and aminoglycoside antibiotics were administered to rabbits. Kanamycin concentration after a single injection of kanamycin with furosemide was much higher in the perilymph and CSF and serum than that after a single injection of kanamycin alone. The antibiotics seems to caused mainly by the inhibitory effect of furosemide on the excretion of aminoglycoside antibiotics from the kidneys.

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