Concomitant development of chronic active hepatitis and antibodies to ribosomal p proteins in a patient with systemic lupus erythematosus

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Abstract
We describe a systemic lupus erythematosus (SLE) patient who for several years had typical SLE features and positive antinuclear antibodies (ANA), including anti–native DNA. Over the course of a year, 4 years after the SLE was diagnosed, the ANA disappeared and antibodies to cytoplasmic component ribosomal P protein (anti‐P) appeared. Associated with the appearance of anti‐P antibodies was the development of biochemical evidence of liver disease, later shown histologically to be chronic active hepatitis. The temporal relationship between the occurrence of anti‐P antibodies and the development of liver disease raises the possibility of a role for anti‐P antibodies in liver disease.