The Influence of Some Anticoagulants and Fibrinolytic Substances on Mice Fibroblasts (Strain L) in Tissue Culture
- 1 January 1961
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 6 (02) , 381-385
- https://doi.org/10.1055/s-0038-1654569
Abstract
The action of some anticoagulants and fibrinolytic substances on the culture of mice fibroblasts is described. Actase and streptokinase show a relatively high toxicity. Beta-heparins are more toxic than alpha-heparins. For pentosans the cytotoxic action is inversely proportional to the molecular weight. Marcoumar is more toxic than coumarin without anticoagulant activity. Variations of the concentration of factors VII, IX and X are of no importance for the cells. Cells 4 hours after explantation are not basically more sensitive than cells 24 hours after explantation.Keywords
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