Methotrexate-vindesine association in head and neck cancer: modification of methotrexate's hydroxylation in presence of vindesine
- 1 June 1986
- journal article
- Published by Springer Nature in Cancer Chemotherapy and Pharmacology
- Vol. 17 (2) , 171-176
- https://doi.org/10.1007/bf00306749
Abstract
High-dose methotrexate (HD-MTX) infusions associated with vindesine (VDS) have been used in the treatment of head and neck cancer. In a previous study, VDS was shown to increase the apparent plasma clearance of MTX.Keywords
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