Correlation between the effects of fosfomycin and chloramphenicol on Escherichia coli
- 1 January 1990
- journal article
- Published by Oxford University Press (OUP) in FEMS Microbiology Letters
- Vol. 66 (1-3) , 129-133
- https://doi.org/10.1016/0378-1097(90)90270-z
Abstract
It was speculated that the increase of the UDP-GlcNAc pool observed with chloramphenicol can modulate the residual PEP: UDP-GlcNAC-enolpyruvate activity of fosfomycin-treated cells. This provided an explanation on how chloramphenicol can insure the formation of enough UDP-Mur-NAc-pentapeptide to sustain peptidoglycan synthesis at a rate that will antogonize fosfomycin-induced lysis.Keywords
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