Synthesis of N6- or 8-substituted 9-(.BETA.-D-arabinofuranosyl)adenines and their antiviral activities against Herpes Simplex and Vaccinia viruses.
- 31 December 1976
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 25 (10) , 2482-2489
- https://doi.org/10.1248/cpb.25.2482
Abstract
9-(.beta.-D-Arabinofuranosyl)adenine (Ara-A) was synthesized from AMP in 30% yield via 8,2''-O-cycloadenosine as an intermediate. Various 8-substituted amino Ara-A derivatives were obtained by aminolysis of 8,2''-O-cycloadenosine and N6-substituted Ara-A derivatives were also obtained by reaction of 6-chloro-9-(.beta.-D-arabinofuranosyl)purine with amines. In vitro antiviral activities of the N6- or 8-substituted Ara-A were determined by the degree of cytopathic effect inhibition [on chick embryo cells].This publication has 0 references indexed in Scilit: