Lack of Human Herpesvirus 8 Infection in Lungs of Japanese Patients with Primary Pulmonary Hypertension
Open Access
- 1 March 2005
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 191 (5) , 743-745
- https://doi.org/10.1086/427824
Abstract
Samples of lung tissue, taken at autopsy, from 10 Japanese patients with primary pulmonary hypertension (PPH) and samples of lung tissue from 12 Japanese patients with secondary pulmonary hypertension were tested for the presence of human herpesvirus 8 (HHV-8). All samples from patients with PPH contained plexiform lesions around pulmonary arterial vessels, but immunohistochemistry failed to detect the HHV-8–encoded latency-associated nuclear antigen. HHV-8 DNA could not be amplified by polymerase chain reaction for the HHV-8–encoded K1 and KS330233 genes in any sample. These data suggest that HHV-8 infection is not associated with PPH in Japanese patientsKeywords
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