CRF–CRF1system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats
- 23 October 2007
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 104 (43) , 17198-17203
- https://doi.org/10.1073/pnas.0707585104
Abstract
Nicotine, the main psychoactive ingredient of tobacco, induces negative emotional symptoms during abstinence that contribute to a profound craving for nicotine. However, the neurobiological mechanisms underlying how nicotine produces dependence remains poorly understood. We demonstrate one mechanism for both the anxiety-like symptoms of withdrawal and excessive nicotine intake observed after abstinence, through recruitment of the extrahypothalamic stress peptide corticotropin-releasing factor (CRF) system and activation of CRF1receptors. Overactivation of the CRF–CRF1system may contribute to nicotine dependence and may represent a prominent target for investigating the vulnerability to tobacco addiction.Keywords
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