Sphingomyelin multiple phase behavior as revealed by multinuclear magnetic resonance spectroscopy
- 1 December 1978
- journal article
- research article
- Published by American Chemical Society (ACS) in Biochemistry
- Vol. 17 (26) , 5745-5750
- https://doi.org/10.1021/bi00619a023
Abstract
31P and 13C NMR spectra were employed to study the phase behavior of bovine brain sphingomyelin as a function of temperature. The 31P NMR data suggested that, while at low temperatures sphingomyelin can form a lamellar phase, at physiological temperatures and higher the lamellar phase is unstable, and a new phase, best described as a hexagonal phase, is formed. Egg phosphatidylcholine may play an important role in stabilizing bilayers in natural membranes. Cholesterol also exhibits a sphingomyelin bilayer-stabilizing ability. The 13C NMR spectra suggest a gelling of the hydrocarbon chains of sphingomyelin at low temperature. Thus, bovine brain sphingomyelin undergoes both a gel to liquid-crystalline phase transition and a lamellar to nonlamellar transition.This publication has 12 references indexed in Scilit:
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