Shutoff of Histone Synthesis by Mengovirus Infection of Ehrlich Ascites Tumor Cells
- 1 January 1977
- journal article
- research article
- Published by Walter de Gruyter GmbH in Hoppe-Seyler´s Zeitschrift Für Physiologische Chemie
- Vol. 358 (1) , 463-474
- https://doi.org/10.1515/bchm2.1977.358.1.463
Abstract
The histone synthesizing capacity of mengovirus-infected [mouse] Ehrlich ascites tumor cells and their corresponding postnuclear supernatants was investigated as a function of post-infection time. Histone synthesis was compared with the synthesis of other basic host proteins under identical conditions. For mengovirus infection of Ehrlich ascites tumor cells, the less complex fraction comprising basic protein, separated from the acidic proteins by CM-cellulose chromatography, represents total host protein. Histones and the remaining basic host proteins are easily identifiable indicators of the host protein synthesizing potential. The cessation of histone synthesis proceeds faster than that of the synthesis of other basic host protein.This publication has 3 references indexed in Scilit:
- Protein Synthesis in Postnuclear Supernatants from Mengovirus-Infected Ehrlich Ascites Tumor CellsHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1975
- Studies on nuclear protein metabolism after infection of Ehrlich ascites cells with maus-elberfeld (ME) virusBiochemical and Biophysical Research Communications, 1964
- Patterns of Macromolecular Synthesis in Normal and Virus-infected Mammalian CellsCold Spring Harbor Symposia on Quantitative Biology, 1961