New Metabolizable Immunologic Adjuvant for Human Use

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Abstract
A MOST critical need for the successful use of killed viral and other nonliving vaccines is a safe and effective immunologic adjuvant. The purpose of such an adjuvant is to achieve a more durable and higher-level immunity employing a smaller antigenic mass in a fewer number of doses than would be attainable with the corresponding aqueous vaccine. Such an adjuvant might find application to polyvalent viral and bacterial vaccines and to allergenic immunizing materials as well. Freund's1 incomplete mineral-oil adjuvant has been used extensively for experimental vaccination in animals and in man. Although this mineral-oil adjuvant has proved to be . . .