Family Studies of Hypergastrinemic, Hyperpepsinogenemic I Duodenal Ulcer

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Abstract
Antral G-cell hyperfunction is a rare cause of hypergastrinemia, hyperchlorhydria and duodenal ulcer disease. Evidence was found for a familial basis for this disorder. The probands were 2 young men with aggressive duodenal ulcer who had basal and postprandial hypergastrinemia, hyperpepsinogenemia I, and basal and pentagastrin-stimulated hyperchlorhydria. All characteristics returned to normal after antrectomy and vagotomy. Antral gastrin concentrations and quantitative G-cell counts were normal, indicating hyperfunction of G-cells rather than hyperplasia. Four of 10 first-degree relatives of the 2 patients shared with them the combination of postprandial hypergastrinemia and hyperpepsinogenemia I. The aggregation of these abnormalities in 2 families, each identified by a proband with hypergastrinemic, hyperpepsinogenemic I duodenal ulcer, suggests that antral G-cell hyperfunction may have a genetic basis.