Massive Glibenclamide Overdose without Hypoglycaemia in a Man with Diabetes after Partial Pancreatectomy
- 1 July 1986
- journal article
- research article
- Published by SAGE Publications in Human Toxicology
- Vol. 5 (4) , 283-284
- https://doi.org/10.1177/096032718600500413
Abstract
A 49-year-old man with non-insulin-dependent diabetes mellitus (NIDDM) from alcoholic pancreatitis took 100 mg of glibenclamide without symptoms of hypoglycaemia even when glibenclamide concentrations were high (191 μg/l). There was no increase in serum C-peptide concentration. The observed half-life of glibenclamide was 6 h. It is concluded that (1) high doses of glibenclamide will not provoke pancreatic insulin secretion in NIDDM caused by pancreatic destruction, (2) there was no evidence for an acute extra-pancreatic effect of glibenclamide and (3) the elimination of glibenclamide may be slower than supposed previously.This publication has 7 references indexed in Scilit:
- Sulfonylureas in the Treatment of Diabetes Mellitus—1985Mayo Clinic Proceedings, 1985
- Relationship between Insulin Secretion and Pancreas Morphology in Subjects with Chronic PancreatitisHormone and Metabolic Research, 1984
- Plasma Levels of Glibenclamide in Diabetic Patients during its Routine Clinical Administration Determined by a Specific RadioimmunoassayHormone and Metabolic Research, 1983
- Comparative Single‐Dose Kinetics and Effects of Four Sulfonylureas in Healthy VolunteersActa Medica Scandinavica, 1980
- Protein Binding and Kinetics of Drugs in Liver DiseasesClinical Pharmacokinetics, 1977
- Effect of oral hypoglycaemic agents on glucose tolerance in pancreatic diabetesGut, 1972
- Etude expérimentale d'un nouveau sulfamide hypoglycémiant particulièrement actif, le HB 419 ou glibenclamideDiabetologia, 1969