Impaired restriction endonuclease cleavage of DNA modified with N-methyl-N-nitrosourea
- 1 August 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 1 (8) , 729-731
- https://doi.org/10.1093/carcin/1.8.729
Abstract
This paper examines the ability of several restriction enzymes to cleave lambda DNA treated in vitro with N-methyl-N-nitrosourea. An impaired digestion was observed with all tested enzymes suggesting that the sequence specific restriction endonucleases are either unable to recognize carcinogen-modified sequences or to insert endonucleolytic cuts at such sites.Keywords
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