Germination of Candida albicans induced by proline

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Abstract
Blastospores of C. albicans germinated in a proline-biotin-buffer medium incubated at 37.degree. C. Certain other amino acids in the glutamate, aspartate and pyruvate families also fostered germination but generally to a lesser extent than did proline. L-Cysteine, D-proline, and certain structural analogues of L-proline inhibited proline-stimulated germination. The concentration of phosphate and glucose was crucial to amino acid-stimulated germination of C. albicans. Clinical isolates and stock cultures varied in their response to the germ tube-inducing activity of proline or other amino acids. The proline-buffer medium cannot be used in a diagnostic test for production of germ tubes by yeast isolates.

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