The β3-Adrenergic Receptor — A Cause and Cure of Obesity?

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Abstract
Obesity affects up to one third of the population in many industrialized countries and increases the risk of several metabolic and cardiovascular disorders. The common belief that obesity results simply from overeating or from a sedentary lifestyle has influenced thinking for a long time. However, it is increasingly apparent that the body has a highly complex and sophisticated system of regulating fat stores and energy balance.1 The adrenergic system plays a major part in controlling energy expenditure. Catecholamines mobilize energy-rich lipids by stimulating lipolysis in fat cells and thermogenesis in brown adipose tissue and skeletal muscle. Originally, these effects were . . .