GUIDE TO ANTIBIOTIC THERAPY OF EXPERIMENTAL BACTERIAL INFECTIONS IN MICE

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Abstract
The 50% effective or curative dose (ED50 or CD50) of a new chemotherapeutic agent against bacterial infections in mice is generally used to determine the efficacy of this agent as compared to that of established antibiotics. The data presented are designed to serve as a working guide to the amounts of antibiotics necessary to obtain satisfactory therapeutic response to several bacterial infections in mice. The antibiotic minimal inhibitory concentrations and ED50 values in vivo (both by subcutaneous and oral routes) of 11 antibiotics for 10 different bacterial infections in mice are presented. When the LD50 challenge is maintained in a given range, replication of the ED50 value is reasonably consistent.

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