The c-KIT mutation causing human mastocytosis is resistant to STI571 and other KIT kinase inhibitors; kinases with enzymatic site mutations show different inhibitor sensitivity profiles than wild-type kinases and those with regulatory-type mutations
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Open Access
- 1 March 2002
- journal article
- Published by American Society of Hematology in Blood
- Vol. 99 (5) , 1741-1744
- https://doi.org/10.1182/blood.v99.5.1741
Abstract
Mutations of c-KIT causing spontaneous activation of the KIT receptor kinase are associated with sporadic adult human mastocytosis (SAHM) and with human gastroiKeywords
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