Electric Transmembrane Potential Mutation and Resistance to the Cationic and Amphiphilic Antitumoral Drugs Derived from Pyridocarbazole, 2-N-Methylellipticinium and2-N-Methyl-9-hydroxyellipticinium, inStreptococcus pneumoniae
- 1 September 1986
- journal article
- research article
- Published by Microbiology Society in Microbiology
- Vol. 132 (9) , 2637-2641
- https://doi.org/10.1099/00221287-132-9-2637
Abstract
.DELTA..psi.-reduced amiA mutants of Streptococcus pneumoniae were shown to be resistant to the positively charged antitumoral drugs 2-N-methylellipticinium (NME) and 2-N-methyl-9-hydroxyellipticinium (NMHE). Conversely, mutants selected for their resistance to NMHE were mapped within the amiA locus and exhibited the pleiotropic AmiA- phenotype. This shows that .DELTA..psi. is a critical parameter in determining resistance to these drgus in S. pneumoniae and suggests that they are accumulated within this bacterium in response to .DELTA..psi.. As a consequence NME and NMHE appear to be valuable tools for selecting .DELTA..psi.-reduced mutants in S. pneumoniae.This publication has 11 references indexed in Scilit:
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