Chronic haemodynamic effects of carvedilol in essential hypertension at rest and during exercise

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Abstract
Nineteen men (mean age 44 years) with essential hypertension, WHO stage I, were studied invasively at rest and during exercise. Blood pressure was recorded in intra-arterially (brachial artery), cardiac output by dye dilution method and heart rate by electrocardiography. After initial pre-drug recordings, the patients received 25 mg carvedilol orally and central haemodynamics at rest and during exercise were recorded 1 and 2 h after tablet in take to evaluate the immediate effects of curvedilol. The results indicated a combined β-blocking and vasodilating effect. After 6–9 months of treatment, supine haemodynamics were recorded 12–24 h after the last dose and then 1 and 2 h after an additional 25 mg dose. During chronic treatment (2 h after last dose at rest supine) mean arterial pressure was reduced by 17% (P 1-blocking activity, particularly in situations with low sympathetic tone. During exercise the β1-blocking activity (demonstrated by the reduction in heart rate) is more prominent.

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