AN INVESTIGATION OF THE EFFECTS OF TNHALED WELDING FUME IN THE RAT
- 1 November 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in Annals of Occupational Hygiene
- Vol. 16 (3) , 213-221
- https://doi.org/10.1093/annhyg/16.3.213
Abstract
Quantitative data on the uptake and distribution of some metallic components of inhaled welding fume have been obtained from studies in rats using instrumental (Ge/Li) neutron activation analysis. Biological effats of short-term exposure have also been studied. In rats exposed to the welding fume for periods of 4 hr substantial lung deposition of iron occurred, and significant increase in the concentrations of cobalt, chromium and antimony were observed. Investigation of subsequent rates of decrease of lung tissue levels revealed that the latter elements were lost more rapidly than the deposited iron; elevated concentrations of cobalt appeared in liver and blood. Only minor histopathological signs of respiratory irritation were observed.Keywords
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